Police fired smoke bombs and tear gas to disperse the protesters who defied a curfew that took effect across the city late Tuesday.
The city is in turmoil after an African-American was killed of injuries suffered from police officers.
Freddie Gray, 25, was killed on April 19 and his funeral was held on Monday.
The black man died one week after hisspinal injury during arrest.
Police said 144 cars were set on fire and 15 buildings were destroyed.
BaltimoreMayor Stephanie Rawlings-Blake imposed the curfew in response to the ongoing protests.
According to Maryland's Gov. Larry Hogan, 2,000 National Guardsmen and 1,000 law officers were deployed to the city following a state of emergency.
This combined force will not tolerate violence or looting, which has led to the destruction of property and put innocent Marylanders at risk,Hogansaid.
Meanwhile, President Barack Obama blamed "criminals and thugs" for the violence.
When individuals get crowbars and start prying open doors to loot, theyre not protesting. Theyre not making a statement. Theyre stealing, Obamasaid.
When they burn down a building, theyre committing arson. And theyre destroying and undermining businesses and opportunities in their own communities. That robs jobs and opportunity from people in that area, he added.
The unrest in Baltimore comes after American authorities ignored protests against police brutality in several cases during the past year.
Many protests were held across the US over the police killings of African-American men, including 18-year-old Michael Brown in Ferguson, Missouri; Eric Garner in New York; and Walter Scott in North Charleston, South Carolina.
Baltimore City Council Member Brandon Scott said the violence was fueled by a long, long, longstanding issue with young African-Americans.
Were talking about years and decades of mistrust, of misfortune, of despair that its just coming out in anger, Scott said. No, it is not right for them to burn down their own city. But that is whats coming out of these young people.
By Press TV
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